The Introduction about Chronic Wounds
Jan 30, 2013

The Introduction about CHRONIC WOUNDS

Chronic wounds represent a significant burden to patients, health care professionals, and the US health care system, affecting 5.7 million patients and costing an estimated 20 billion dollars annually.1

A chronic wound is a wound that does not heal in an orderly set of stages and in a predictable amount of time the way most wounds do; wounds that do not heal within three months are often considered chronic.2 Chronic wounds seem to be detained in one or more of the phases of wound healing. For example, chronic wounds often remain in the inflammatory stage for too long.3,4 In acute wounds, there is a precise balance between production and degradation of molecules such as collagen; in chronic wounds this balance is lost and degradation plays too large a role.5,6

 

Chronic wounds may never heal or may take years to do so. These wounds cause patients severe emotional and physical stress and create a significant financial burden on patients and the whole healthcare system.7

 
Reference

1.      Branski LK, Gauglitz GG, Herndon DN, et al. A review of gene and stem cell therapy in cutaneous wound healing. Burns. Jul 4 2008.
2.     Mustoe T (March 17–18, 2005). "Dermal ulcer healing: Advances in understanding". Tissue repair and ulcer/wound healing: molecular mechanisms, therapeutic targets and future directions. Paris, France: EUROCONFERENCES.
3.     Snyder, Robert J. (2005). "Treatment of nonhealing ulcers with allografts". Clinics in Dermatology23 (4): 388–95.
4.     Taylor, Jennifer E.; Laity, Peter R.; Hicks, John; Wong, Steven S.; Norris, Keith; Khunkamchoo, Peck; Johnson, Anthony F.; Cameron, Ruth E. (2005). "Extent of iron pick-up in deforoxamine-coupled polyurethane materials for therapy of chronic wounds". Biomaterials 26 (30): 6024–33.
5.     Edwards, J; Howley, P; Cohen, IK (2004). "In vitro inhibition of human neutrophil elastase by oleic acid albumin formulations from derivatized cotton wound dressings". International Journal of Pharmaceutics 284 (1–2): 1–12.
6.     Schönfelder, Ute; Abel, Martin; Wiegand, Cornelia; Klemm, Dieter; Elsner, Peter; Hipler, Uta-Christina (2005). "Influence of selected wound dressings on PMN elastase in chronic wound fluid and their antioxidative potential in vitro". Biomaterials 26 (33): 6664–73.
7.      Augustin, M.; Maier, K. (2003). "Psychosomatic Aspects of Chronic Wounds". Dermatology and Psychosomatics 4: 5.
8.      Moreo, Kathleen (2005). "Understanding and overcoming the challenges of effective case management for patients with chronic wounds". The Case Manager 16 (2): 62–3, 67.
9.      Mustoe, Thomas (2004). "Understanding chronic wounds: A unifying hypothesis on their pathogenesis and implications for therapy". The American Journal of Surgery 187 (5): S65.
10.     Velander, Patrik E.; Theopold, Christoph; Gheerardyn, Raphael; Bleiziffer, Oliver; Yao, Feng; Eriksson, Elof (2004). "Autologous cultured keratinocytes suspensions accelerate re-epithelialization in the diabetic pig". Journal of the American College of Surgeons 199 (3): 58.
11.     Supp, Dorothy M.; Boyce, Steven T. (2005). "Engineered skin substitutes: Practices and potentials". Clinics in Dermatology 23 (4): 403–12.
12.     Thomas, David R.; Diebold, Marilyn R.; Eggemeyer, Linda M. (2005). "A controlled, randomized, comparative study of a radiant heat bandage on the healing of stage 3–4 pressure ulcers: A pilot study". Journal of the American Medical Directors Association 6 (1): 46–9.
13.     Pressure ulcers: Surgical treatment and principles at eMedicine.
14.     Supp, Dorothy M.; Boyce, Steven T. (2005). "Engineered skin substitutes: Practices and potentials". Clinics in Dermatology 23 (4): 403–12.

15.     Crovetti, Giovanni; Martinelli, Giovanna; Issi, Marwan; Barone, Marilde; Guizzardi, Marco; Campanati, Barbara; Moroni, Marco; Carabelli, Angelo (2004). "Platelet gel for healing cutaneous chronic wounds". Transfusion and Apheresis Science 30 (2): 145–51.
16.     Moreo, Kathleen (2005). "Understanding and overcoming the challenges of effective case management for patients with chronic wounds". The Case Manager 16 (2): 62–3, 67.
17.     Velander, Patrik E.; Theopold, Christoph; Gheerardyn, Raphael; Bleiziffer, Oliver; Yao, Feng; Eriksson, Elof (2004). "Autologous cultured keratinocytes suspensions accelerate re-epithelialization in the diabetic pig". Journal of the American College of Surgeons 199 (3): 58.