Diabetic Ulcers
Jan 30, 2013

Diabetic ulcers:

Another major cause of chronic wounds, diabetes, is increasing in prevalence.10 Diabetics have a 15% higher risk for amputation than the general population3 due to chronic ulcers. Diabetes causes neuropathy, which inhibits nociception and the perception of pain.3 Thus patients may not initially notice small wounds to legs and feet, and may therefore fail to prevent infection or repeated injury.8 Further, diabetes causes immune compromise and damage to small blood vessels, preventing adequate oxygenation of tissue, which can cause chronic wounds.8 Pressure also plays a role in the formation of diabetic ulcers.9



Reference

1.      Branski LK, Gauglitz GG, Herndon DN, et al. A review of gene and stem cell therapy in cutaneous wound healing. Burns. Jul 4 2008.
2.     Mustoe T (March 17–18, 2005). "Dermal ulcer healing: Advances in understanding". Tissue repair and ulcer/wound healing: molecular mechanisms, therapeutic targets and future directions. Paris, France: EUROCONFERENCES.
3.     Snyder, Robert J. (2005). "Treatment of nonhealing ulcers with allografts". Clinics in Dermatology23 (4): 388–95.
4.     Taylor, Jennifer E.; Laity, Peter R.; Hicks, John; Wong, Steven S.; Norris, Keith; Khunkamchoo, Peck; Johnson, Anthony F.; Cameron, Ruth E. (2005). "Extent of iron pick-up in deforoxamine-coupled polyurethane materials for therapy of chronic wounds". Biomaterials 26 (30): 6024–33.
5.     Edwards, J; Howley, P; Cohen, IK (2004). "In vitro inhibition of human neutrophil elastase by oleic acid albumin formulations from derivatized cotton wound dressings". International Journal of Pharmaceutics 284 (1–2): 1–12.
6.     Schönfelder, Ute; Abel, Martin; Wiegand, Cornelia; Klemm, Dieter; Elsner, Peter; Hipler, Uta-Christina (2005). "Influence of selected wound dressings on PMN elastase in chronic wound fluid and their antioxidative potential in vitro". Biomaterials 26 (33): 6664–73.
7.      Augustin, M.; Maier, K. (2003). "Psychosomatic Aspects of Chronic Wounds". Dermatology and Psychosomatics 4: 5.
8.      Moreo, Kathleen (2005). "Understanding and overcoming the challenges of effective case management for patients with chronic wounds". The Case Manager 16 (2): 62–3, 67.
9.      Mustoe, Thomas (2004). "Understanding chronic wounds: A unifying hypothesis on their pathogenesis and implications for therapy". The American Journal of Surgery 187 (5): S65.
10.     Velander, Patrik E.; Theopold, Christoph; Gheerardyn, Raphael; Bleiziffer, Oliver; Yao, Feng; Eriksson, Elof (2004). "Autologous cultured keratinocytes suspensions accelerate re-epithelialization in the diabetic pig". Journal of the American College of Surgeons 199 (3): 58.
11.     Supp, Dorothy M.; Boyce, Steven T. (2005). "Engineered skin substitutes: Practices and potentials". Clinics in Dermatology 23 (4): 403–12.
12.     Thomas, David R.; Diebold, Marilyn R.; Eggemeyer, Linda M. (2005). "A controlled, randomized, comparative study of a radiant heat bandage on the healing of stage 3–4 pressure ulcers: A pilot study". Journal of the American Medical Directors Association 6 (1): 46–9.
13.     Pressure ulcers: Surgical treatment and principles at eMedicine.
14.     Supp, Dorothy M.; Boyce, Steven T. (2005). "Engineered skin substitutes: Practices and potentials". Clinics in Dermatology 23 (4): 403–12.

15.     Crovetti, Giovanni; Martinelli, Giovanna; Issi, Marwan; Barone, Marilde; Guizzardi, Marco; Campanati, Barbara; Moroni, Marco; Carabelli, Angelo (2004). "Platelet gel for healing cutaneous chronic wounds". Transfusion and Apheresis Science 30 (2): 145–51.
16.     Moreo, Kathleen (2005). "Understanding and overcoming the challenges of effective case management for patients with chronic wounds". The Case Manager 16 (2): 62–3, 67.
17.     Velander, Patrik E.; Theopold, Christoph; Gheerardyn, Raphael; Bleiziffer, Oliver; Yao, Feng; Eriksson, Elof (2004). "Autologous cultured keratinocytes suspensions accelerate re-epithelialization in the diabetic pig". Journal of the American College of Surgeons 199 (3): 58.