Pressure Ulcers
Jan 30, 2013

5. Pressure ulcers:

Another leading type of chronic wounds is pressure ulcers,11 which usually occur in people with conditions such as paralysis that inhibit movement of body parts that are commonly subjected to pressure such as the heels, shoulder blades, and sacrum.12,13 Pressure ulcers are caused by ischemia that occurs when pressure on the tissue is greater than the pressure in capillaries, and thus restricts blood flow into the area.11 Muscle tissue, which needs more oxygen and nutrients than skin does, shows the worst effects from prolonged pressure.13 As in other chronic ulcers, reperfusion injury damages tissue.


Reference

1.      Branski LK, Gauglitz GG, Herndon DN, et al. A review of gene and stem cell therapy in cutaneous wound healing. Burns. Jul 4 2008.
2.     Mustoe T (March 17–18, 2005). "Dermal ulcer healing: Advances in understanding". Tissue repair and ulcer/wound healing: molecular mechanisms, therapeutic targets and future directions. Paris, France: EUROCONFERENCES.
3.     Snyder, Robert J. (2005). "Treatment of nonhealing ulcers with allografts". Clinics in Dermatology23 (4): 388–95.
4.     Taylor, Jennifer E.; Laity, Peter R.; Hicks, John; Wong, Steven S.; Norris, Keith; Khunkamchoo, Peck; Johnson, Anthony F.; Cameron, Ruth E. (2005). "Extent of iron pick-up in deforoxamine-coupled polyurethane materials for therapy of chronic wounds". Biomaterials 26 (30): 6024–33.
5.     Edwards, J; Howley, P; Cohen, IK (2004). "In vitro inhibition of human neutrophil elastase by oleic acid albumin formulations from derivatized cotton wound dressings". International Journal of Pharmaceutics 284 (1–2): 1–12.
6.     Schönfelder, Ute; Abel, Martin; Wiegand, Cornelia; Klemm, Dieter; Elsner, Peter; Hipler, Uta-Christina (2005). "Influence of selected wound dressings on PMN elastase in chronic wound fluid and their antioxidative potential in vitro". Biomaterials 26 (33): 6664–73.
7.      Augustin, M.; Maier, K. (2003). "Psychosomatic Aspects of Chronic Wounds". Dermatology and Psychosomatics 4: 5.
8.      Moreo, Kathleen (2005). "Understanding and overcoming the challenges of effective case management for patients with chronic wounds". The Case Manager 16 (2): 62–3, 67.
9.      Mustoe, Thomas (2004). "Understanding chronic wounds: A unifying hypothesis on their pathogenesis and implications for therapy". The American Journal of Surgery 187 (5): S65.
10.     Velander, Patrik E.; Theopold, Christoph; Gheerardyn, Raphael; Bleiziffer, Oliver; Yao, Feng; Eriksson, Elof (2004). "Autologous cultured keratinocytes suspensions accelerate re-epithelialization in the diabetic pig". Journal of the American College of Surgeons 199 (3): 58.
11.     Supp, Dorothy M.; Boyce, Steven T. (2005). "Engineered skin substitutes: Practices and potentials". Clinics in Dermatology 23 (4): 403–12.
12.     Thomas, David R.; Diebold, Marilyn R.; Eggemeyer, Linda M. (2005). "A controlled, randomized, comparative study of a radiant heat bandage on the healing of stage 3–4 pressure ulcers: A pilot study". Journal of the American Medical Directors Association 6 (1): 46–9.
13.     Pressure ulcers: Surgical treatment and principles at eMedicine.
14.     Supp, Dorothy M.; Boyce, Steven T. (2005). "Engineered skin substitutes: Practices and potentials". Clinics in Dermatology 23 (4): 403–12.

15.     Crovetti, Giovanni; Martinelli, Giovanna; Issi, Marwan; Barone, Marilde; Guizzardi, Marco; Campanati, Barbara; Moroni, Marco; Carabelli, Angelo (2004). "Platelet gel for healing cutaneous chronic wounds". Transfusion and Apheresis Science 30 (2): 145–51.
16.     Moreo, Kathleen (2005). "Understanding and overcoming the challenges of effective case management for patients with chronic wounds". The Case Manager 16 (2): 62–3, 67.
17.     Velander, Patrik E.; Theopold, Christoph; Gheerardyn, Raphael; Bleiziffer, Oliver; Yao, Feng; Eriksson, Elof (2004). "Autologous cultured keratinocytes suspensions accelerate re-epithelialization in the diabetic pig". Journal of the American College of Surgeons 199 (3): 58.